Premier League champions Manchester United will open the 2013/2014 season at Swansea.
The fixture sees David Moyes take charge of his first league game as United boss against the same side that Sir Alex Ferguson faced in his last home game before retirement.
Jose Mourinho, meanwhile, will begin the start of his second spell in charge of Chelsea against newly promoted Hull City and last season's runners-up Manchester City host Newcastle in what will be Manuel Pellegrini's first league game in charge.
Elsewhere, Championship play-off winners Crystal Palace will host Tottenham in a London derby, while Arsenal host Aston Villa and Stoke visit Liverpool.
The first heavyweight contest of the season sees Manchester United entertain Chelsea at Old Trafford and a week later Moyes will take his new side to Anfield to face Liverpool on the same day Arsenal host Tottenham in the north London derby.
The first meeting of the Manchester powerhouses is due to take place on September 21 at the Etihad Stadium, while the return fixture is scheduled for March 1.
United will complete their league fixtures against Southampton at St Mary’s, while rivals Manchester City are scheduled to entertain West Ham on the final day. Chelsea will finish against last season’s Championship winners Cardiff, while Arsenal are due to travel to Norwich and Tottenham will host Aston Villa.
